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Single molecule imaging of neurons with photo-functional quantum dots

Yasuko Osakada

Osaka University,
The Institute of Scientific and Industrial Research
Assistant Professor

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Research Theme

Neurons are the basic building blocks of the nervous system, maintaining its functions in living cells with dynamic changes. The major goal of my research is development of novel, real time, single-molecule imaging systems for understanding neuronal networks that regulate these neuronal activities. This proposal seeks to functionalize quantum dots with photoswitchable molecules upon photoactivation. By modulating the photophysical properties of quantum dots using light, we visualize neuronal processes directly at single molecule levels. These techniques will enhance understanding how various neuronal processes and signaling pathways affect the neuronal networks.